Written by Brian K. Vaughan. Art by Pia Guerra and jose Marzan, Jr. Cover by J.G. Jones.

Did you ever wonder what it would be like being the last man on earth, well now is your chance. Y the last man is about a plague that wipes out every mammal on the face of the earth with the Y chromosone, except for one man, Yorick Brown and his pet male monkey. He must survive extremists while he searches for his girlfriend on the other side of the globe. Why is he the only man left alive?